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Custom Synthesis

Alfa Chemistry can provide custom synthesis of a wide variety of quaternary ammonium compounds in order to meet your requirements in the shortest time. Custom synthesis of quaternary ammonium compounds enables researchers to focus on what they are good at, speed up research and development progress, and avoid wasting valuable time on compound synthesis.

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Alfa Chemistry can provide custom synthesis of a wide variety of quaternary ammonium compounds. Here, take several typical synthesis of quaternary ammonium salts as an example.

  • Halide Quaternary Ammonium Salts

The mainly synthesis way of halide quaternary ammonium salts is Menschutkin reaction which converts a tertiary amine into a quaternary ammonium salt by reaction with an alkyl halide. This reaction occurs at an aliphatic carbon with a stable, electronegative leaving group (halide). The breaking of the carbon-halide bond and the formation of the new nitrogen-carbon bond occurs simultaneously during the transition state. In solutions, final products exist as separate ions, ion pairs or solid salts.

Synthesis route diagram of halide quaternary ammonium salt.Figure 1. Synthesis route diagram of halide quaternary ammonium salt.

  • Acid Radical Quaternary Ammonium Salts

Here, take the TBAHS (tetrabutylammonium hydrogen sulfate) for example. TBAHS can be prepared from tetrabutylammonium azide by treating it with potassium hydrogen sulfate and 10% aqueous sulfuric acid in aqueous medium.

Synthesis of tetrabutylammonium hydrogen sulfate.Figure 2. Synthesis of tetrabutylammonium hydrogen sulfate.

  • Quaternary Ammonium Hydroxide

Quaternary ammonium hydroxides may be obtained by treatment of an aqueous solution of a quaternary ammonium iodide with an excess of moist silver oxide. Among them, silver iodide is precipitated. Quaternary ammonium hydroxides can be obtained by filtration and concentration of the filtrate.

Synthesis of quaternary ammonium hydroxides.Figure 3. Synthesis of quaternary ammonium hydroxides.

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Alfa Chemistry provides the design and formulate reasonable solution to meet your requirements. We have extensive experience in custom synthesis of quaternary ammonium compounds. We ensure high-quality standards and complete delivery on time. Generally, your inquiry will be resolved within 48 hours after receiving the request. We will promptly provide the approximate price and delivery time of the project. If you want to know more about custom synthesis of quaternary ammonium salt, please contact us.