Codling, C. E., et al. Journal of Antimicrobial Chemotherapy 51.5 (2003): 1153-1158.
Polyquaternium-1 (PQ-1) and myristoylpropyl dimethylamine (MAPD), two antimicrobial agents commercially used in contact lens disinfectants, were investigated for their potential mechanisms of action against a range of common ocular pathogens.
Antimicrobial Efficacy
Substantial differences in the activity of PQ-1 and MAPD against different organisms were observed. Aspergillus fumigatus and Candida albicans were resistant to PQ-1 but were very sensitive to MAPD. The former was more active against these three bacteria than against the other microorganisms. Among these bacteria, Staphylococcus aureus was the most susceptible and Staphylococcus marcescens the least susceptible. MAPD showed a broader range of activity and was active against all organisms. It showed higher inhibitory activity against Candida carinii at very low concentrations, higher inhibitory activity against both fungi at moderate concentrations, and higher inhibitory activity against bacteria at higher concentrations.
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