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Horner, Ian J., et al. The Journal of Physical Chemistry B 119.33 (2015): 10531-10542.
Polyquaternium-1 (PQ-1) is a cationic polymer widely used as a preservative in multipurpose contact lens solutions (MPS) due to its antimicrobial efficacy. This study investigates its interaction with corneal epithelial biomembrane models using fluorescence spectroscopy, dynamic light scattering (DLS), and liquid chromatography-mass spectrometry (LC-MS).
Experimental results reveal that PQ-1 exhibits a unique interaction mechanism with small unilamellar vesicle (SUV) bilayers mimicking the corneal membrane. Unlike polyhexamethylene biguanide (PHMB), which increases bilayer rigidity by layering onto the membrane surface, PQ-1 intercalates into the bilayer and between different SUVs. This interaction reduces phospholipid-phospholipid cooperativity, increases water content within the acyl chain region, and enhances membrane dynamics. The loosening of the bilayer structure may facilitate better diffusion of active compounds, yet excessive destabilization could impact biocompatibility.
These findings highlight PQ-1's role in MPS formulations, where its membrane-modulating properties influence preservative efficacy and ocular surface interactions. Understanding these molecular interactions provides insight into the design of next-generation ophthalmic preservatives, balancing antimicrobial potency with corneal biocompatibility.
