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Pan, Animesh, et al. Journal of Colloid and Interface Science 518 (2018): 225-233.
Decyltrimethylammonium bromide (C10TAB), a cationic surfactant, plays a crucial role in the self-assembly of nanostructures, forming pH-dependent mixed micelles and vesicles when combined with anionic bolaamphiphiles (HOOC-(CH2)n-COOH). This study investigates the formation and stability of C10TAB-based micelles and vesicles at varying pH conditions, revealing distinct structural transitions.
At high pH (pH > 8), C10TAB forms mixed micelles with dicarboxylic acid bolas, exhibiting sizes between 6.24 and 7.43 nm. As the pH decreases (pH 6-8), the micellar structures transition into vesicles, with sizes ranging from ~30-70 nm (small vesicles) to ~220-296 nm (large vesicles). At low pH (<6), an inhomogeneous oil-like phase emerges, indicating phase separation and the presence of free acid species. The critical micelle concentration (CMC), micellization energetics, and structural characterization were determined using ITC, DLS, and LCSM, confirming the stability of vesicles for over a month.
Fluorescence anisotropy studies further validate the vesicle formation, which transitions into micelles at elevated temperatures. The ability of C10TAB to form stable, pH-responsive mixed micelles and vesicles highlights its potential in drug delivery, nanocarrier design, and controlled-release applications. This study underscores C10TAB's versatility in surfactant-assisted self-assembly, making it a valuable component in nanotechnology and biopharmaceutical formulations.
